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公司介绍 // introduction

        Romics隶属上海真金炸金花游戏下载科技有限公司致力于表观遗传学在科学研究和临床检测上的应用,是上海市高新技术企业,博士后流动站。在科研服务领域,团队主要产品线有ChIP-seq,ATAC-seq,单细胞ATAC-seq,CUT&Tag,1微克MeRIP-seq,HiChIP以及普通RNA-seq和单细胞RNA-seq;在临床检测领域,团队开发了一整套针对cfDNA甲基化的实验检测技术和数据分析技术,相关应用产品正在临床实验阶段。

       真金炸金花游戏下载的ChIP-seq技术协助客户发表论文十余篇,近一年所发表的杂志包括Nature Communications,PNAS和Theranostics等;2018年8月1日真金炸金花游戏下载发布了十万样本ATAC-seq测序计划,该计划受到哈佛大学刘小乐教授,北京大学李程教授,和同济大学江赐忠教授的高度点评;2019年1月,真金炸金花游戏下载的ATAC-seq实验技术协助客户于The Journal of Clinical Investigation发表论文Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer,影响因子12.282分;2019年3月,真金炸金花游戏下载通过了美国10X Genomics 公司的单细胞ATAC-seq产品线的CSP认证,成为国际上首家获得该产品官方认证的企业。此外,2018年9月,真金炸金花游戏下载于Plos  Biology杂志发表1微克RNA的MeRIP-seq实验文章 Refined RIP-seq protocol for epitranscriptome analysis with low input materials,开启了MeRIP-seq技术进入临床医学研究的序幕。

真金炸金花游戏下载参与发表的文章列表//article

人和动物的文章:        

1. Comparative analysis ofmetazoan chromatin organization. Nature(IF: 40.136)

2. JARID1B is a luminallineage-driving oncogene in breast cancer. Cancer Cell(IF: 27.407)

3. Distinct Role ofNuclear Receptor Corepressor 1 regulated de novo fatty acids synthesis in liverregeneration and hepatocarcinogenesis. Hepatology (IF: 13.246)

4. Integrating Gene andMir Expression Profiles and Regulatory Network Structures to Define AberrentFeed Forward Loops with Functional and Clinical Implications in Myeloma. Blood(IF: 13.164)

5. Integrative genomicanalyses reveal clinically relevant long non-coding RNA in human cancer. NatStruct Mol Biol(IF: 12.595)

6. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer.Journal of Clinical Investigation(IF: 12.282)

7. Transcriptionfactor-pathway coexpression analysis reveals cooperation between SP1 and ESR1on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma.Leukemia(IF: 12.104)

8. Computational inferenceof mRNA stability from histone modification and transcriptome profiles. NucleicAcids Res(IF: 10.162)

9. Conditional knockin ofDnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.Proc Natl Acad Sci U S A(IF: 9.661)

10. Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival.Theranostics(IF: 8.063)

11. BSeQC: Quality Controlof Bisulfite Sequencing Experiments. Bioinformatics(IF: 7.307)

12. CistromeFinder forChIP-seq and DNase-seq data reuse. Bioinformatics(IF: 7.307)

13. DistinctTranscriptional and Alternative Splicing Signatures of Decidual CD4+ T Cells inEarly Human Pregnancy. Front Immunol(IF: 6.4)

14. All-trans retinoicacid and arsenic trioxide fail to derepress the monocytic differentiationdriver Irf8 in acute promyelocytic leukemia cells. Cell Death Dis(IF: 5.965)

15. Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane.Aging-US(IF: 5.515)

16. PHF8 and REST/NRSFco-occupy gene promoters to regulate proximal gene expression. SciRep(IF: 4.259)

17. ProFITS of maize: adatabase of protein families involved in the transduction of signaling in themaize genome. BMC Genomics(IF: 3.729)

18. Classify hyperdiploidystatus of multiple myeloma patients using gene expression profiles. PLoSOne(IF: 2.806)

植物的文章:        

1. PlantGSEA: a gene setenrichment analysis toolkit for plant community. Nucleic Acids Res(IF: 10.162)

2. agriGO: a GO analysistoolkit for the agricultural community. Nucleic Acids Res(IF: 10.162) (Highlycited and recommended by Faculty of 1000 Biology: http://f1000.com/3302956)

3. Genome-wide analysis of histone modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativaL. Japonica. Mol Plant(IF: 8.827)

4. Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana. PLOS Genetics (IF: 6.1)

5. plantsUPS: a databaseof plants’ Ubiquitin Proteasome System. BMC Genomics(IF: 3.729)


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